Edwards was born in Hannibal, Missouri. He left school at age 14 and soon moved to St. Louis, Missouri and Saint Charles, Missouri, where he entertained as a singer in saloons. As many places had pianos in bad shape or none at all, Edwards taught himself to play ukulele to serve as his own accompanist (choosing it because it was the cheapest instrument in the music shop). He was nicknamed "Ukulele Ike" by a club owner who could never remember his name. He got his first break in 1918 at the Arsonia Cafe in Chicago, Illinois, where he performed a song called "Ja-Da", written by the club's pianist, Bob Carleton. Edwards and Carleton made it a hit on the vaudeville circuit. Vaudeville headliner Joe Frisco hired Edwards as part of his act, which was featured at the Palace in New York City, the most prestigious vaudeville theater, and later in the Ziegfeld Follies. Edwards made his first phonograph records in 1919. He recorded early examples of jazz scat singing in 1922. The following year he signed a contract with Pathé Records. He became one of the most popular singers of that decade, appearing in several Broadway shows. He recorded many of the pop and novelty hits of the day, including "California, Here I Come", "Hard Hearted Hannah", "Yes Sir, That's My Baby", and "I'll See You In My Dreams". In 1924, Edwards performed as the headliner at the Palace, the pinnacle of vaudeville success. Also in that year, he was featured in George Gershwin and Ira Gershwin's first Broadway musical Lady Be Good, alongside Fred and Adele Astaire. In 1925, his recording of "Paddlin’ Madeleine Home" reached number three on the pop charts. His recording of "I Can't Give You Anything but Love" was number one for one week on the U.S. pop singles chart in 1928. The following year, his recording of "Singin' In The Rain" was number one for three weeks. Edwards's own compositions included "(I'm Cryin' 'Cause I Know I'm) Losing You", "You're So Cute (Mama O' Mine)", "Little Somebody Of Mine", and "I Want To Call You 'Sweet Mama'". He also recorded a few "off-color" novelty songs for under-the-counter sales, including "I'm A Bear In A Lady's Boudoir" and "Give It To Mary With Love". Edwards, more than any other performer, was responsible for the soaring popularity of the ukulele. Millions of ukuleles were sold during the decade, and Tin Pan Alley publishers added ukulele chords to standard sheet music. Edwards always played American Martin ukuleles favoring the small soprano model in his early career. In his later years, he moved to the sweeter, large tenor ukulele more suitable for crooning, which was becoming popular in the 1930s. Edwards' continued to record until shortly before his 1971 death. His last record album, Ukulele Ike, was released posthumously on the independent Glendale label. He reprised many of his 1920s hits, but his failing health was evident in the recordings. In 1929, Cliff Edwards was playing at the Orpheum Theater in Los Angeles, California, where he caught the attention of movie producer-director Irving Thalberg. His film company Metro-Goldwyn-Mayer hired Edwards to appear in early sound movies. After performing in some short films, Edwards was one of the stars in the feature Hollywood Revue of 1929, doing some comic bits and singing some numbers, including the film debut of his hit "Singin' in the Rain". He appeared in a total of 33 films for MGM through 1933. He had a small role as Mike, playing a ukulele very briefly at the beginning of the 1931 movie Laughing Sinners (1931), starring Joan Crawford. Edwards was very friendly with MGM's comedy star Buster Keaton, who featured Edwards in three of his films. Keaton, himself a former vaudevillian, enjoyed singing and would harmonize with Edwards between takes. One of these casual jam sessions was captured on film, in Doughboys (1930), in which Buster and Cliff scat-sing their way through "You Never Did That Before". Buster was battling a drinking problem at the time, and Cliff was nursing a drug habit, both of which are evident in the finished film. In scenes when Keaton is sharp and alert, Edwards appears befuddled; when Edwards regains his sobriety, Keaton is now stumbling and fumbling. (Edwards was ultimately replaced in the Keaton films by Jimmy Durante.) Edwards was also an occasional supporting player in feature films and short subjects at Warner Brothers and RKO Radio Pictures. He played a wisecracking sidekick to western star George O'Brien, and filled in for Allen Jenkins as "Goldie" opposite Tom Conway in The Falcon Strikes Back. In a 1940 short, he led a cowboy chorus in Cliff Edwards and His Buckaroos. Throughout the 1940s he appeared in a number of "B" westerns playing the comic, singing sidekick to the hero, seven times with Charles Starrett and six with Tim Holt. Edwards appeared in the darkly sardonic western comedy The Bad Man of Brimstone (1937), and he played the character "Endicott" in the screwball comedy film His Girl Friday (1940). In 1939, he voiced the off-screen dying Confederate soldier in Gone with the Wind in the makeshift hospital scene with Vivien Leigh and Olivia De Havilland casting large shadows on a church wall. His most famous voice role was as Jiminy Cricket in Walt Disney's Pinocchio (1940). Edwards's rendition of "When You Wish Upon A Star" is probably his most familiar recorded legacy. He voiced the head crow in Disney's Dumbo (1941) and sang "When I See An Elephant Fly". In 1932, Edwards had his first national radio show on CBS Radio. He continued hosting network radio shows through 1946. In the early 1930s, however, Edwards' popularity faded as public taste shifted to crooners such as Russ Columbo, Rudy Vallee, and Bing Crosby. Arthur Godfrey's use of the ukulele spurred a surge in its popularity and those that played it, including Edwards. Like many vaudeville stars, Edwards was an early arrival on television. In the 1949 season, he starred in The Cliff Edwards Show, a three-days-a-week (Monday, Wednesday, and Friday evenings) TV variety show on CBS. In the 1950s and early 1960s, he made appearances on The Mickey Mouse Club, in addition to performing his Jiminy Cricket voice for various Disney shorts and the Disney Christmas spectacular, From All of Us to All of You. Edwards was careless with the money he made in the 1920s, always trying to sustain his expensive habits and lifestyle. He continued working during the Great Depression, but he would never again enjoy his former prosperity. Most of his income went to alimony for his three former wives and paying debts. He declared bankruptcy four times during the 1930s and early 1940s. Edwards married his first wife Gertrude Ryrholm in 1919, but they divorced four years later. He married Irene Wylie in 1923; they divorced in 1931. In 1932, he married his third and final wife, actress Judith Barrett. They divorced in 1936. Edwards suffered from alcoholism and drug addiction in his later years, and was also a heavy smoker for most of his life. Living in a home for indigent actors, Edwards often spent his time at the Walt Disney Studios to be available any time he could get voice work. He was sometimes taken to lunch by animators whom he told stories of his days in vaudeville. He had nearly disappeared from the public eye at the time of his death in 1971 from a cardiac arrest brought on by arteriosclerosis. Now penniless, Edwards was a charity patient at the Virgil Convalescent Hospital in Hollywood, California. His body was unclaimed and was donated to the University of California, Los Angeles medical school. When Walt Disney Productions, who had been quietly paying many of his medical expenses, discovered this, they offered to purchase his remains and pay for the burial. Instead, it was done by the Actors' Fund of America (which had also aided Edwards) and the Motion Picture and Television Relief Fund. Disney paid for his grave marker. In 2002, Edwards' 1940 recording on Victor, Victor 26477, "When You Wish Upon A Star", was inducted into the Grammy Hall of Fame. In 2000, Edwards was awarded as a Disney Legend for voice-acting.