TWiV 1005: COVID T vax and a virus from the b...

Paul Bieniasz joins TWiV to discuss his lab's discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites ...  Afficher plus

In his weekly clinical update, Daniel Griffin and Vincent Racaniello delve into dengue virus infections in Florida, recent human rabies infections in the US, proposed changes in biomedical funding including "converting" the Department of War into NIAID, the continuing controversy ...  Afficher plus

Hosts: Vincent Racaniello, Dickson Despommier, and Josef Sabo Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins. Links for this episode: S. japonicum tetraspanin-2 as a vaccine target (PLoS NTP) Prote ...  Afficher plus

Nels and Vincent review the identification of a novel virus associated with the pathogen Plasmodium knowlsei and which is part part of a diverse and unclassified viral taxon. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of T ...  Afficher plus

Nels and Vincent explain how deep genomics of macroalgae illuminate multiple paths to aquatic, photosynthetic multicellularity.

Hosts: Nels Elde and Vincent Racaniello< ...

TWiM explains how a mutualistic model bacterium can become lethal in a non-symbiotic host, and engineering a kill switch into a tuberculosis vaccine for improved safety. Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Subscribe to TWiM (free) on Apple ...  Afficher plus