LK-99 breakthrough with Varda's Delian Asparo...

This Week In Startups is made possible by: Plaud: https://plaud.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Vanta: https://www.vanta.com/twist Rippling: https://rippling.ai/twist Today’s show: Jason can’t stop praising Nathan Fielder’ ...  Show more

This Week In Startups is made possible by: Lightfield: https://lightfield.app Every.io: https://every.io/ PayPal: https://paypal.com/business Plaud: https://plaud.ai/twist GoDaddy: https://www.godaddy.com/ Today’s show: Today’s college grads are showing up to work at Jason’s comp ...  Show more

Today on the flagship podcast of payment processing fees: 04:36 - The Verge's David Pierce travels to meet Keegan McNamara, an artisan who is making unique computers for more purposeful use cases. A visit to the one-man computer factory 27:11 - Liz Lopatto and Alex Heath join the ...  Show more

Open Source bi-weekly convo w/ Bill Gurley and Brad Gerstner on all things tech, markets, investing & capitalism. This week, guest host Altimeter’s Apoorv Agrawal explores how OpenAI is reshaping enterprise with Sherwin Wu, Head of Engineering OpenAI Platform, and Olivier Godemen ...  Show more

There's never been a better time to start an AI company. Not just because there are new ideas, but because the tech finally makes old ones actually work.On the Lightcone, Garry, Harj, Diana, and Jared talk through the kinds of startups that are suddenly viable thanks to LLMs—from ...  Show more

Show Notes:

0:00 Big week for the besties: Friedberg's new raise, Sacks' new fund & more

16:30 Innovative venture strategies: internal mark ups, venture studios, deployment strategies

30:44 Zymergen's implosion: role of diligence, how to make deep tech sus ...