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CTX310 and the Future of Gene Editing for Lipid Disorders

Steven Nissen, MD, and Luke Laffin, MD, discuss one-year follow-up data for CTX310, a CRISPR-Cas9 gene-editing therapy targeting ANGPTL3 to treat lipid disorders. They review the sustained reductions in LDL cholesterol and triglycerides, and the potential role of one-time gene-ed ...  Show more

Evaluating Kylo-11 for Long-Acting Lipoprotein(a) Suppression

Steven Nissen, MD, and Ashish Sarraju, MD, discuss early clinical data on Kylo-11, a novel therapy that produced substantial reductions in lipoprotein(a) for up to one year after a single injection. Lowering lipoprotein(a), a genetically determined cardiovascular risk factor link ...  Show more

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