Piperacillin/Tazobactam Pharmacology

P2Y12 inhibitors are a cornerstone of antiplatelet therapy in cardiovascular disease. These agents block the P2Y12 receptor on platelets, preventing ADP-mediated activation and reducing platelet aggregation. By inhibiting this amplification pathway, they help prevent arterial thr ...  Show more

In this episode, we explore several important non-statin cholesterol-lowering therapies, focusing on their mechanisms, clinical uses, and practical considerations for patient care. We start with bile acid sequestrants, also known as resins, including cholestyramine, colestipol, a ...  Show more

In this episode, we discuss the evidence, safety, and place in therapy of Journavx® (suzetrigine), a newly approved analgesic with a unique non-opioid mechanism of action and additional considerations for its use. Key Concepts Suzetrigine is a first in its class NaV1.8 sodium cha ...  Show more

Contributor: Jorge Chalit-Hernandez, OMS3

Educational Pearls:

CYP enzymes are responsible for the metabolism of many medications, drugs, and other substances

Contributor: Ricky Dhaliwal, MD

Educational Pearls: 

Ketorolac and ibuprofen are NSAIDs with equivalent efficacy for pain in the emergency depar ...

In this episode, we discuss the approach to deprescribing for several drugs such as benzodiazepine receptor agonists, cholinesterase inhibitors, memantine, antipsychotics, and antihyperglycemics. Key Concepts Medication appropriateness including indication and risk vs. benefit sh ...  Show more