NEJM This Week — October 16, 2025

This week, we look at ctDNA-guided immunotherapy for bladder cancer, cardiovascular outcomes with tirzepatide, and evidence that one HPV vaccine dose may be enough. We explore high-dose rifampin for tuberculous meningitis, review measles amid rising outbreaks, and follow a challe ...  Show more

This week, we look at new studies on high-dose influenza vaccines for older adults, antiplatelet therapy after coronary surgery, and HER2-targeted immunotherapy for advanced bladder cancer. We review complex regional pain syndrome and a pediatric case of fever and rash. We also e ...  Show more

Trials of a cancer 'vaccine' have begun and presenter James meets Steve, one of the first patients to trial the new treatment, Steve remembers his shock at being diagnosed with colorectal cancer in his 40s and tells the story of how he became involved in this pioneering research ...  Show more

For the past few months, measles has been in regular rotation in the news cycle here in the US, with outbreaks occurring across the country in regions with low vaccine uptake. These outbreaks represent a worrying trend in the rejection of scientific and medical expertise, with lo ...  Show more

Drs Michael S. Saag and David H. Spach discuss HIV and the nuances of primary care treatment, with a special focus on vaccines, including COVID, hepatitis, varicella zoster virus, and mpox. Relevant disclosures can be found with the episode show notes on Medscape ( https://www.med ...  Show more

En 2023, l’OMS et l’Unicef constataient une stagnation de la couverture vaccinale infantile dans le monde, entraînant une recrudescence de certaines maladies, comme la rougeole. Pourtant, les jeunes enfants sont davantage exposés aux risques de complications de ces maladies, la m ...  Show more