Jeanne Baret
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The Chevalier d'Éon was a diplomat, spy, traitor, and international celebrity. She's also sometimes regarded as one of the most prominent transgender figures in European history.
Hortense Mancini is perhaps most famous for being a royal mistress, but her life was a series of adventures and scandals. Hortense was willing to do whatever it took to be a woman who lived on her own terms in the 17th century.