Cardiac Consult: A Cleveland Clinic Podcast f...

Cleveland Clinic Heart & Vascular Institute

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CTX310 and the Future of Gene Editing for Lipid Disorders

Steven Nissen, MD, and Luke Laffin, MD, discuss one-year follow-up data for CTX310, a CRISPR-Cas9 gene-editing therapy targeting ANGPTL3 to treat lipid disorders. They review the sustained reductions in LDL cholesterol and triglycerides, and the potential role of one-time gene-ed ... Show more

. 6min 25sec

Evaluating Kylo-11 for Long-Acting Lipoprotein(a) Suppression

Steven Nissen, MD, and Ashish Sarraju, MD, discuss early clinical data on Kylo-11, a novel therapy that produced substantial reductions in lipoprotein(a) for up to one year after a single injection. Lowering lipoprotein(a), a genetically determined cardiovascular risk factor link ... Show more

. 7min 43sec

Robotic Approaches to Mitral and Aortic Valve Surgery

Marc Gillinov, MD, and Per Wierup, MD, discuss the evolution of robotic valve surgery, including advanced mitral valve repair techniques, patient selection and expanding applications for aortic valve and coronary procedures. They examine how enhanced visualization, instrument dex ... Show more

. 9min 49sec

Infective Endocarditis Diagnosis and Management

Bo Xu, MD, and Shinya Unai, MD, discuss approaches to diagnosing and treating infective endocarditis, including indications for surgical intervention. The conversation highlights the role of multimodality imaging , individualized surgical planning and multidisciplinary care strat ... Show more

. 12min 32sec

Expanding Coronary Revascularization With TECAB

Donna Kimmaliardjuk, MD, and Gianluca Torregrossa, MD, discuss the expanding role of robotic coronary artery bypass grafting, including total endoscopic coronary artery bypass (TECAB). They explore how a tailored surgical approach can improve long-term patient outcomes.Looking to ... Show more

. 22min 51sec